As mentioned, oral and injectable steroids cause a negative feedback after a certain level and duration of usage. A signal is sent to the hypothalamohypophysial testicular axis since the steroids give the hypothalamus an incorrect signal. The hypothalamus, in turn, signals the hypophysis to reduce or stop the production of FSH (follicle stimulating hormone) and of LH. Thus, the testosterone production decreases since the testosterone-producing Leydig's cells in the testes, due to decreased LH, are no longer sufficiently stimulated. Since the body usually needs a certain amount of time to get its testosterone production going again, the athlete, after discontinuing steroid compounds, experiences a difficult transition phase which often goes hand in hand with a considerable loss in both strength and muscle mass. Administering HCG directly after steroid treatment helps to reduce this condition because HCG increases the testosterone production in the testes very quickly and reliably. In the event of testicular atrophy caused by megadoses and very long periods of usage, HCG also helps to quickly bring the testes back to their original condition (size). Since occasional injections of HCG during steroid intake can avoid a testicular atrophy, many athletes use HCG for two to three weeks in the middle of their steroid treatment. It is often observed that during this time the athlete makes his best progress with respect to gains in both strength and muscle mass. The reasons for this is clear. On the one hand, by taking HCG the athlete's own testosterone level immediately jumps up and, on the other hand, a large concentration of anabolic substances in the blood is induced by the steroids. Many bodybuilders, powerlifters, and weightlifters report a lower sex drive at the end of a difficult workout cycle, immediately before or after a competition, and especially toward the end of a steroid treatment. Athletes who have often taken steroids in the past usually accept this fact since they know that it is a temporary condition. Those, however who are on the juice all year round, who might suffer psychological consequences or who would perhaps risk the breakup of a relationship because of this should consider this drawback when taking HCG in regular intervals. A reduced libido and spermatogenesis due to steroids in most cases, can be successfully cured by treatment with HCG.
Most athletes, however, use HCG Pregnyl 5000iu at the end of a treatment in order to avoid a "crash," that is, to achieve the best possible transition into "natural training." A precondition, however, is that the steroid intake or dosage be reduced slowly and evenly before taking HCG. Although HCG causes a quick and significant increase of the endogenic plasmatestosterone level, unfortunately it is not a perfect remedy to prevent the loss of strength and mass at the end of a steroid treatment. The athlete will only experience a delayed re-adjustment, as has often been observed. Although HCG does stimulate endogenous testosterone production, it does not help in reestablishing the normal hypothalamic/pituitary testicular axis. The hypothalamus and pituitary are still in a refractory state after prolonged steroid usage, and remain this way while HCG is being used, because the endogenous testosterone produced as a result of the exogenous HCG represses the endogenous LH production. Once the HCG is discontinued, the athlete must still go through a re-adjustment period. This is merely delayed by the HCG use. For this reason experienced athletes often take Clomid and Clenbuterol following HCG intake or they immediately begin another steroid treatment. Some take HCG merely to get off the "steroids" for at least two to three weeks.